An endocrine pathway: The HPA axis.
When stimulated, hypothalamic neurons secrete corticotropin-releasing hormone (CRH) into the primary capillary plexus of the hypophyseal portal system. CRH travels down the hypophyseal portal veins into the secondary capillary plexus, stimulating the release of adrenocorticotropic hormone (ACTH a.k.a. corticotropin) from the corticotroph cells of the anterior pituitary gland (or adenohypophysis). ACTH travels through the body's blood vessels, stimulating the adren
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